清末民初,佛山武学宗师黄飞鸿因噩梦预感女记者莫十三遇险,携弟子前往古云村寻人。村中蜈蚣教借蛊术胁迫村民献祭孩童,莫十三探查真相时被擒,身中噬魂蛊。黄飞鸿闯祭坛救人,因不忍伤及被蛊惑的村民反中蛊毒(dú ),幸(xìng )得(dé )卧(wò )底(dǐ )蜈(wú )蚣(gōng )教(jiāo )的(de )鬼(guǐ )脚(jiǎo )七(qī )暗(àn )中(zhōng )相(xiàng )助(zhù )。众(zhòng )人(rén )合(hé )力破除水源蛊毒,救治村民,鬼脚七伤愈拜师。巫师自焚后,线索指向广州东瀛会馆。黄飞鸿潜入会馆救出被掳孩童,对决主事服部一郎,得知幕后黑手为西洋吸血鬼麦克罗。麦克罗散播疫毒祸乱羊城,以莫十三性命相要挟。黄飞鸿于绝境中融合腿法,悟出佛山无(wú )影(yǐng )脚(jiǎo ),击(jī )杀(shā )麦(mài )克(kè )罗(luó )。蛊(gǔ )毒(dú )尽(jìn )解(jiě ),百(bǎi )姓(xìng )恢(huī )复(fù )神(shén )智(zhì ),广州重归太平,宝芝林重回烟火日常。